Visiting Professor, NIH
Sabbatical Fellowship, Bone Tissue Engineering Center,
Carnegie Mellon University, 2000
Postdoctoral Research Associate, McArdle Laboratory
for Cancer Research, University of Wisconsin-Madison,
1988-1991
NIH Postdoctoral Fellow, Department of Physiological
Chemistry, University of Wisconsin-Madison, 1985-1988
Ph.D. Genetics, University of California-Berkeley,
1985
A.B. Biology, College of the Holy Cross, 1978 |
|
The goal of tissue engineering
is to replace diseased or damaged living tissue
with living tissue designed and constructed for
the needs of each individual. Remarkable advances
across many areas of science in the last decade
have moved tissue engineering from promise to
reality. Medical science is moving from transplantation
into an era of design and fabrication of tissue
and organ replacements. Several tissue engineered
products are already on the market. Dr. Doctor's
lab at Duquesne is involved in multidisciplinary
studies of tissue engineering and biomaterials
evaluation in collaboration with labs at Duquesne
and the Bone Tissue Engineering Center at Carnegie
Mellon University, and the McGowan Institute for
Regenerative Medicine at the University of Pittsburgh.
Current research in the Doctor Lab employs a broad
range of approaches using cellular and molecular
biology. Some projects include evaluating
methods to culture adult stem cells and bone cells
in three-dimensions as cell delivery vehicles
for tissue engineering, examining the hormonal
control of bone cell development, and assessing
the biocompatibility of various biomaterials.
Representative Publications:
1. Guelcher SA, Gallagher K, Didier JE, Doctor JS, Beckman EJ, Hollinger JO (2005). A new synthesis strategy to prepare biocompatible polyurethanes for tissue engineering. Acta Biomaterialia 1, 471-484.
2. Guelcher SA, Patel V, Gallagher KM, Connolly S, Didier JE, Doctor JS, Hollinger JO. Synthesis and in vitro biocompatibility of injectable polyurethane foam scaffolds. Tissue Engineering, in press.
3. Radio NM , Doctor JS, Witt-Enderby PA. Melatonin, melatonin receptors, and MEK/ERK (1/2) affect alkaline phosphatase activity in human adult mesenchymal stem cells. Submitted, Journal of Pineal Research.
4. Bender M, Bennett JM, Waddell, R, Doctor JS, Marra KG (2004). Multi-channeled biodegradable polymer/CultiSpher composite nerve guides. Biomaterials 25, 1269-1278.
5. Waddell RL, Marra KG, Collins KL, Leung JT, Doctor JS (2003). Evaluation of poly(caprolactone) and collagenous microcarriers for applications in nerve guide fabrication using PC12 cells. Biotechnology Progress 19, 1767-1774.
Check out these links:
* About
John Doctor
* The
Pittsburgh Tissue Engineering Initiative
* The
Bone Tissue Engineering Center at Carnegie Mellon
University
Office Phone: 412.396.5615
Email: doctor@duq.edu |
