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Research Biologist, Carnegie
Mellon University, 2001
Postdoctoral Fellow, Carnegie Mellon University,
1995
Ph.D. Biochemistry, Uninversity of Kentucky, 1991
B.S. Biochemistry, University of Wyoming, 1985
Research
Interests
Phospholipid metabolism is intimately
coupled to the physiological status of the cell.
As cells and organelles change size and shape
with events such as cell division, secretion,
and membrane biogenesis, phospholipids are continually
broken down and resynthesized in a controlled
manner. The regulation of phospholipid biosynthesis
and degradation must take into account not only
the concentrations and locations of individual
phospholipid species, but also the production
of lipid-derived second messenger molecules, the
transport of molecules across membranes, and the
environmental conditions under which the cells
are growing. Employing the powerful molecular
genetic tools provided by the model eukaryote
Saccharomyces cerevisiae, my research focuses
on the mechanisms by which the cell coordinates
phospholipid metabolism with the complex cellular
events for which it is crucial. This work is supported
by a grant from the National Institutes of Health.
Representative Publications:
1. Patton-Vogt, J. (2007) Transport and metabolism of glycerophosphodiesters produced through phospholipid deacylation. Biochim. Biophys. Acta., 1771:337-342.
2. Boumann HA, J. Gubbens, M.C. Koorengevel, C.S. Oh, C.E. Martin, A.J. Heck, J. Patton-Vogt, S.A. Henry, B. de Kruijff, A.I. de Kroon (2006) Depletion of phosphatidylcholine in yeast induces shortening and increased saturation of the lipid acyl chains: evidence for regulation of intrinsic membrane curvature in a eukaryote. Mol. Biol. Cell. 17:1006-17. 3. Almaguer, C., E. Fisher, J. Patton-Vogt (2006) Posttranscriptional regulation of Git1p, the glycerophosphoinositol/glycerophosphocholine transporter of Saccharomyces cerevisiae. Curr Genet., 50(6):367-75.
4. Mariggio, S., C. Iurisci, J. Sebastia, J. Patton-Vogt and D. Corda (2006). "Molecular characterization of a glycerophosphoinositol transporter in mammalian cells." FEBS Lett 580(30): 6789-96.
5. Fisher, E., C. Almaguer, R. Holic, P. Griac, J. Patton-Vogt (2005) Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae. J. Biol. Chem. 280:36110-7.
6. Almaguer, C. Cheng, W. Nolder, C., and Patton-Vogt, J. Glycerophosphoinositol, a novel phosphate source whose transport is regulated by multiple factors in Saccharomyces cerevisiae. (2004) J. Biol. Chem. 279, 31937-31942.
7. Almaguer, C., Mantella, D., Perez, E., and Patton-Vogt, J. Inositol and phosphate regulate GIT1 transcription and glycerophosphoinositol incorporation in Saccharomyces cerevisiae. (2003) Eukaryotic Cell . 2, 729-736.
8. Dowd, S.R., Bier, M.E., and Patton-Vogt, J.L. Turnover of phosphatidylcholine in Saccharomyces cerevisiae (2001) J. Biol. Chem 276, 3756-3763.
9. Shirra, K.S., Patton-Vogt, J.L., Ulrich, A., Liuta-Tehlivets, O., Kohlwein, S.D., Henry, S.A., and Arndt, K.M. Inhibition of acetyl-CoA carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae. (2001) Mol. Cell. Biol. 21, 5710-5722.
10. Srinivas, A., Patton-Vogt, J.L., Bruno, V., and Henry, S.A. A role for the major phospholipase D (Pld1p) in the secretory pathway in yeast. (1998) J. Biol. Chem 273, 16635-16638.
11. Patton-Vogt, J.L. and Henry, S.A. (1998) GIT1, a gene encoding a novel transporter for glycerophosphoinositol in Saccharomyces cerevisiae. Genetics 149, 1707-1715.
12. Henry, S.A. and Patton-Vogt, J.L. (1998) Genetic regulation of phospholipid metabolism in yeast. Progress in Nucleic Acid Research and Molecular Biology 61, 133-179. (Invited review)
13. Patton-Vogt, J.L., Griac, P., Srinivas, A., Bruno, V., Dowd, S., Swede, M. and Henry, S.A. (1997) Role of the yeast phosphatidylcholine/phosphatidylinositol transfer protein (Sec14p) in phosphatidylcholine turnover and INO1 regulation. J. Biol. Chem. 272, 20873-20883.
14. Patton, J. L., Pessoa-Brandao, L., and Henry, S. A. (1995) Production and utilization of an extracellular phosphatidylinositol catabolite, glycerophosphoinositol, by Saccharomyces cerevisiae. J. Bacteriol. 177, 3379-3385.
Office Phone: 412.396.1053
Email: pattonvogt@duq.edu |
